Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test
Identifieur interne : 001991 ( Main/Corpus ); précédent : 001990; suivant : 001992Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test
Auteurs : Marcus M. Unger ; Jens C. Möller ; Katharina Mankel ; Katrin Schmittinger ; Karla M. Eggert ; Maria Stamelou ; Karin Stiasny-Kolster ; Katharina Bohne ; Maren Bodden ; Geert Mayer ; Wolfgang H. Oertel ; Johannes J. TebbeSource :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
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- KwdEn :
Abstract
Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23933
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Möller</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mankel, Katharina" sort="Mankel, Katharina" uniqKey="Mankel K" first="Katharina" last="Mankel">Katharina Mankel</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schmittinger, Katrin" sort="Schmittinger, Katrin" uniqKey="Schmittinger K" first="Katrin" last="Schmittinger">Katrin Schmittinger</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. 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Tebbe</name><affiliation><mods:affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23933</idno><idno type="url">https://api.istex.fr/document/AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test</title><author><name sortKey="Unger, Marcus M" sort="Unger, Marcus M" uniqKey="Unger M" first="Marcus M." last="Unger">Marcus M. Unger</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C." last="Möller">Jens C. Möller</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mankel, Katharina" sort="Mankel, Katharina" uniqKey="Mankel K" first="Katharina" last="Mankel">Katharina Mankel</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schmittinger, Katrin" sort="Schmittinger, Katrin" uniqKey="Schmittinger K" first="Katrin" last="Schmittinger">Katrin Schmittinger</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bohne, Katharina" sort="Bohne, Katharina" uniqKey="Bohne K" first="Katharina" last="Bohne">Katharina Bohne</name><affiliation><mods:affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bodden, Maren" sort="Bodden, Maren" uniqKey="Bodden M" first="Maren" last="Bodden">Maren Bodden</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Hephata Clinic for Neurology, Schwalmstadt‐Treysa, Germany</mods:affiliation></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation><mods:affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J." last="Tebbe">Johannes J. Tebbe</name><affiliation><mods:affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2559">2559</biblScope><biblScope unit="page" to="2563">2563</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F</idno><idno type="DOI">10.1002/mds.23933</idno><idno type="ArticleID">MDS23933</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>13C‐octanoate breath test</term><term>PD</term><term>Parkinson's disease</term><term>RBD</term><term>REM sleep behavior disorder</term><term>gastric emptying</term><term>gastric motility</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marcus M. Unger MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Jens C. Möller MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Katharina Mankel MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Katrin Schmittinger MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Karla M. Eggert MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Maria Stamelou MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Karin Stiasny‐Kolster MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Katharina Bohne MD</name><affiliations><json:string>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Maren Bodden PhD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Geert Mayer MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string><json:string>Department of Neurology, Hephata Clinic for Neurology, Schwalmstadt‐Treysa, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang H. Oertel MD</name><affiliations><json:string>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Johannes J. Tebbe MD</name><affiliations><json:string>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</json:string><json:string>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>REM sleep behavior disorder</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>RBD</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PD</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gastric emptying</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gastric motility</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>13C‐octanoate breath test</value></json:item></subject><articleId><json:string>MDS23933</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P > .001) and in treated Parkinson's disease patients (P > .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.908</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1207</abstractCharCount><pdfWordCount>12490</pdfWordCount><pdfCharCount>83283</pdfCharCount><pdfPageCount>20</pdfPageCount><abstractWordCount>159</abstractWordCount></qualityIndicators><title>Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>2563</last><first>2559</first></pages><issn><json:string>0885-3185</json:string></issn><issue>14</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23933</json:string></doi><id>AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: Michael J. Fox Foundation for Parkinson's Research (to M.M.U. and W.H.O.).</note><note type="content">*Relevant conflicts of interest/financial disclosures: The authors declare that there is no conflict of interest regarding this work.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test</title><author><persName><forename type="first">Marcus M.</forename><surname>Unger</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Philipps‐Universität Marburg, Baldingerstrasse, 35043 Marburg, Germany</p></note><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Jens C.</forename><surname>Möller</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Katharina</forename><surname>Mankel</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Katrin</forename><surname>Schmittinger</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Karla M.</forename><surname>Eggert</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Maria</forename><surname>Stamelou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Karin</forename><surname>Stiasny‐Kolster</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Katharina</forename><surname>Bohne</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Maren</forename><surname>Bodden</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Geert</forename><surname>Mayer</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><affiliation>Department of Neurology, Hephata Clinic for Neurology, Schwalmstadt‐Treysa, Germany</affiliation></author><author><persName><forename type="first">Wolfgang H.</forename><surname>Oertel</surname></persName><roleName type="degree">MD</roleName><note type="biography">Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</note><affiliation>Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</affiliation><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author><persName><forename type="first">Johannes J.</forename><surname>Tebbe</surname></persName><roleName type="degree">MD</roleName><note type="biography">Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</note><affiliation>Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</affiliation><affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</affiliation><affiliation>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2559">2559</biblScope><biblScope unit="page" to="2563">2563</biblScope></imprint></monogr><idno type="istex">AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F</idno><idno type="DOI">10.1002/mds.23933</idno><idno type="ArticleID">MDS23933</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>REM sleep behavior disorder</term></item><item><term>RBD</term></item><item><term>Parkinson's disease</term></item><item><term>PD</term></item><item><term>gastric emptying</term></item><item><term>gastric motility</term></item><item><term>13C‐octanoate breath test</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-04-07">Received</change><change when="2011-08-02">Registration</change><change when="2011-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="140"><doi origin="wiley" registered="yes">10.1002/mds.v26.14</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">14</numbering></numberingGroup><coverDate startDate="2011-12">December 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="250" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23933</doi><idGroup><id type="unit" value="MDS23933"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2011-04-07"></event><event type="manuscriptRevised" date="2011-07-27"></event><event type="manuscriptAccepted" date="2011-08-02"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-08-24"></event><event type="publishedOnlineFinalForm" date="2011-12-14"></event><event type="firstOnline" date="2011-08-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2559</numbering><numbering type="pageLast">2563</numbering></numberingGroup><correspondenceTo>Department of Neurology, Philipps‐Universität Marburg, Baldingerstrasse, 35043 Marburg, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23933.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="17"></count><count type="wordTotal" number="3574"></count></countGroup><titleGroup><title type="main" xml:lang="en">Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the <sup>13</sup>C‐octanoate breath test<link href="#fn3"></link><link href="#fn4"></link><link href="#fn5"></link></title><title type="short" xml:lang="en">Gastric Motility in iRBD and PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Marcus M.</givenNames><familyName>Unger</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="marcus.unger@med.uni-marburg.de">marcus.unger@med.uni‐marburg.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jens C.</givenNames><familyName>Möller</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Katharina</givenNames><familyName>Mankel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Katrin</givenNames><familyName>Schmittinger</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Karla M.</givenNames><familyName>Eggert</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Maria</givenNames><familyName>Stamelou</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Karin</givenNames><familyName>Stiasny‐Kolster</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Katharina</givenNames><familyName>Bohne</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Maren</givenNames><familyName>Bodden</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Geert</givenNames><familyName>Mayer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1" noteRef="#fn7"><personName><givenNames>Wolfgang H.</givenNames><familyName>Oertel</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af3 #af4" noteRef="#fn7"><personName><givenNames>Johannes J.</givenNames><familyName>Tebbe</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, Hephata Clinic for Neurology, Schwalmstadt‐Treysa, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">REM sleep behavior disorder</keyword><keyword xml:id="kwd2">RBD</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">PD</keyword><keyword xml:id="kwd5">gastric emptying</keyword><keyword xml:id="kwd6">gastric motility</keyword><keyword xml:id="kwd7"><sup>13</sup>C‐octanoate breath test</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the <sup>13</sup>C‐octanoate breath test.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Gastric emptying was significantly delayed in drug‐naïve (<i>P</i> < .001) and in treated Parkinson's disease patients (<i>P</i> < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the <sup>13</sup>C‐octanoate breath test. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Funding agencies: Michael J. Fox Foundation for Parkinson's Research (to M.M.U. and W.H.O.).</p></note><note xml:id="fn4"><p>Relevant conflicts of interest/financial disclosures: The authors declare that there is no conflict of interest regarding this work.</p></note><note xml:id="fn5"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note><note xml:id="fn7"><p>Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Gastric Motility in iRBD and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the</title></titleInfo><name type="personal"><namePart type="given">Marcus M.</namePart><namePart type="family">Unger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><description>Correspondence: Department of Neurology, Philipps‐Universität Marburg, Baldingerstrasse, 35043 Marburg, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens C.</namePart><namePart type="family">Möller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katharina</namePart><namePart type="family">Mankel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katrin</namePart><namePart type="family">Schmittinger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karla M.</namePart><namePart type="family">Eggert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Stamelou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karin</namePart><namePart type="family">Stiasny‐Kolster</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katharina</namePart><namePart type="family">Bohne</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maren</namePart><namePart type="family">Bodden</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geert</namePart><namePart type="family">Mayer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><affiliation>Department of Neurology, Hephata Clinic for Neurology, Schwalmstadt‐Treysa, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Oertel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Philipps‐University Marburg, Marburg, Germany</affiliation><description>Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes J.</namePart><namePart type="family">Tebbe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Internal Medicine, Philipps‐University Marburg, Marburg, Germany</affiliation><affiliation>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold, Germany</affiliation><description>Dr. Oertel and Dr. Tebbe contributed equally to the manuscript.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-12</dateIssued><dateCaptured encoding="w3cdtf">2011-04-07</dateCaptured><dateValid encoding="w3cdtf">2011-08-02</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">17</extent><extent unit="words">3574</extent></physicalDescription><abstract lang="en">Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: Michael J. Fox Foundation for Parkinson's Research (to M.M.U. and W.H.O.).</note><note type="content">*Relevant conflicts of interest/financial disclosures: The authors declare that there is no conflict of interest regarding this work.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>REM sleep behavior disorder</topic><topic>RBD</topic><topic>Parkinson's disease</topic><topic>PD</topic><topic>gastric emptying</topic><topic>gastric motility</topic><topic>13C‐octanoate breath test</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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